Thus, as well as the enhanced glycolysis, IDH2 diverts the glycolytic intermediates to serine and you may glycine synthesis, which is necessary for the fresh bioenergetic demand and precursors you to service cancers development

To predict the potential metabolic vulnerability of IDH2 we applied GSMM, incorporating the proteomic data of the IDH2-perturbed cell lines. Constraint-based modeling with the iMAT algorithm computed the most likely metabolic activity in the cells, and the minimization of metabolic adjustment (MOMA) algorithm was then used to predict the protein essentiality only in IDH2-high cells. Continue reading …